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KMID : 1156220060320050492
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Journal of Environmental Health Sciences
2006 Volume.32 No. 5 p.492 ~ p.498
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Effects of Natural Extracts on UVB-induced Pigmentation and Inflammation in C57BL/6 Mouse Skin
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Choi Wook-Hee
Jin So-Young
Choi Tae-Youn
Ann Hyoung-Soo
Ann Ryoung-Me
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Abstract
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Ultraviolet(UV) radiation causes a variety of biological effects on the skin, including inflammation, pigmentation, photoaging and cancer. Free radicals are involved in inflammatory skin reactions induced by UVB radiation. In this study, we investigated the effects of antioxidants(Tea, Korean red ginseng, Ginkgo biloba extract) on UVB-induced skin damage. Tea, KRG and EGb 761 were topically treated to dorsal skin of ICR mouse. The mice were also treated soon after 1MED (1.4 KJ/㎡) of UVB irradiation. Skin pigmentation of irradiated mouse was observed by a chromameter after 2 weeks. Topical application of Tea, KRG and EGb 761 for 2 weeks decreased skin pigmentation compared to UVB control group(p＜.05). Tea, KRG and EGb 761 also reduced UVB-induced infiltration of inflammatory cells. These results showed that Tea, KRG and EGb 761 as a topical application may have preventive effect against UVB-induced skin damage.
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KEYWORD
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UVB radiation, Korean red ginseng(KRG), Ginkgo biloba extract(EGb 761), tea
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