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KMID : 1156220120380050380
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Journal of Environmental Health Sciences
2012 Volume.38 No. 5 p.380 ~ p.385
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Pallidal Signal Intensities on T1-weighted MRI are Highly Observed in Advanced Liver Cirrhosis
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Weon Young-Cheol
Kim Yang-Ho
Lee Heun
Park Neung-Hwa
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Abstract
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Background: Manganese (Mn) has been found to increase the signal intensity of the globus pallidus (GP) on T1-weighted magnetic resonance images (MRI). We performed this study in order to determine the features of liver disease that correlate with pallidal signal intensities.
Methods: We assessed blood Mn levels and pallidal signals in T1-weighted MRI in 49 patients with liver cirrhosis and 23 healthy controls.
Results: Increased signal intensity in the GP was observed in 30 of 49 (61.2%) patients with liver cirrhosis, with the pallidal index (PI) in patients with Child-Pugh classes B and C differing significantly from the PI in controls. Multiple linear regression analysis showed that blood Mn concentrations and Child-Pugh scores in cirrhotics were significantly associated with increased PI after controlling for other confounders (p<0.05 each).
Conclusions: Pallidal signals on T1-weighted MRI are mainly observed in advanced liver cirrhosis. The present study suggests that advanced liver cirrhosis may be a human model for manganism.
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KEYWORD
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manganese, signal intensity, magnetic resonance, liver cirrhosis, pallidal index
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