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KMID : 1156220170430010023
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Journal of Environmental Health Sciences
2017 Volume.43 No. 1 p.23 ~ p.41
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Prioritization of Chemicals for Chronic/Carcinogenic Inhalation Testing
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Rim Kyung-Taek
Lim Cheol-Hong
Kim Hyeon-Young
Cha Shin-Woo
Heo Yong
Yoon Jin-Ha
Kim Hyoung-Ah
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Abstract
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Objectives: In this study, we seek to perform a priority selection for test substances for chronic inhalation toxicity studies, including acute and subchronic inhalation toxicity studies, which are to be performed after the construction of a chronic/carcinogenicity inhalation toxicity study facility and enactment of pertinent legislation.
Methods: Through this study, qualitative and quantitative priority evaluation of test substances according to acute, subchronic and chronic categories were respectively performed and priorities were suggested by expert group review, redundancy and other methods. Meanwhile, a draft on test substance selection criteria, procedures and methods referring to the National Toxicology Program (NTP) system was proposed.
Results: This study selected priorities for candidate substances for chronic inhalation toxicity studies to be conducted from 2016.
Conclusions: In the future, by assessing in advance the toxicological effects of chemicals to which workers can be potentially exposed in the workplace via long-term inhalation, expected health disturbances among workers will be reduced and it is anticipated that occupational disease induced by chemicals will be effectively prevented.
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KEYWORD
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Carcinogenicity , Chronic , Inhalation , Toxicity , Selection , Test substance
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