|
KMID : 1157520140100010031
|
|
International Journal of Clinical Preventive Dentistry
2014 Volume.10 No. 1 p.31 ~ p.36
|
|
|
The Exposure Amount of Paraben from Commercial Toothpaste
|
|
Ahn Geum-Sun
Park Yong-Duk
Yoo Su-Min
|
|
|
Abstract
|
|
|
Objective: Parabens, which have cytotoxic activity, are widely used preservatives in personal care products. In this study, theexposure amounts of paraben during toothpaste usage were predicted by analyze the paraben concentration in commercialdentifrices using high-performance liquid chromatography.
Methods: Commercial toothpaste from different manufacturer were extracted in methanol, diluted with distilled water tomake concentration 0.5 mg/L. Four parabens (methylparaben, ethylparaben, propylparaben, and butylparaben) in toothpastesamples were separated by high-performance liquid chromatography using C18 column and 50% acetonitrile at 20oC, thendetected at ultraviolet 256 nm.
Results: The analytical method showed good precision and accuracy. Any parabens weren’t detected in toothpastes from onemanufacturer, and were detected in toothpastes from other two manufacturer except ethylparabens. The exposed total parabensper one brushing was maximally 1.8 mg.
Conclusion: The amount of parabens from toothpaste was predicted to be insignificant compared to other routes (cosmetics,foods); however, it is need to minimize the use of parabens in toothpaste.
|
|
|
KEYWORD
|
|
|
parabens, toothpastes, mouth mucosa, chromatography
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
|
|