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KMID : 1161320200350020113
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Journal of Animal Reproduciton and Biotechnology
2020 Volume.35 No. 2 p.113 ~ p.118
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The role of hepatic stellate cells in fibrotic liver diseases
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Cho Hye-Jin
Jang Jae-Young
Kim Tae-Min
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Abstract
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Hepatic stellate cells (HSCs) play essential roles in normal and pathophysiological function in liver. In steady state, HSCs contribute to retinoid storage, immune tolerance, and extracellular matrix (ECM) homeostasis. Upon liver injury, they become activated and lead to morphological and functional changes. Studies have demonstrated that activation of HSCs by various stimuli such as toxins, microbial infection, or metabolic overload can promote the fibrotic changes in liver by production of ECM. Herein, we provide current knowledge about the basic characteristics of HSCs and the mechanism by which they are activated.
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KEYWORD
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hepatic stellate cells, liver fibrosis, liver injury
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