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KMID : 1161320210360040175
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Journal of Animal Reproduciton and Biotechnology
2021 Volume.36 No. 4 p.175 ~ p.182
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Porcine OCT4 reporter system as a tool for monitoring pluripotency states
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Kim Seung-Hun
Lee Chang-Kyu
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Abstract
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Pluripotent stem cells could self-renew and differentiate into various cells. In particular, porcine pluripotent stem cells are useful for preclinical therapy, transgenic animals, and agricultural usage. These stem cells have na?ve and primed pluripotent states. Na?ve pluripotent stem cells represented by mouse embryonic stem cells form chimeras after blastocyst injection. Primed pluripotent stem cells represented by mouse epiblast stem cells and human embryonic stem cells. They could not produce chimeras after blastocyst injection. Populations of embryonic stem cells are not homogenous; therefore, reporter systems are used to clarify the status of stem cells and to isolate the cells. For this reason, studies of the OCT4 reporter system have been conducted for decades. This review will discuss the na?ve and primed pluripotent states and recent progress in the development of porcine OCT4 reporter systems.
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KEYWORD
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naive, oct4, pig, primed, reporter, stem cell
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