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KMID : 1161420100130010216
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Journal of Medicinal Food
2010 Volume.13 No. 1 p.216 ~ p.218
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Effects of Coenzyme Q10 Supplementation on Plasma Adiponectin, Interleukin-6, and Tumor Necrosis Factor-α Levels in Men
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Gokbel Hakki
Gergerlioglu Hasan Serdar
Okudan Nilsel
Gul Ibrahim
Buyukbas Sadik
Belviranli Muaz
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Abstract
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The aim of the study was to determine the effects of coenzyme Q10 supplementation on plasma adiponectin, interleukin (IL)-6, and tumor necrosis factor (TNF?)-α levels in sedentary men. Fourteen healthy, nonsmoking, sedentary men participated in the study. The protocol was approved by the Ethical Committee of our institution. This study was a randomized, double-blind, crossover trial. Blood samples were collected from all participants before coenzyme Q10 or placebo supplementation. The participants were randomly allocated to two groups. Seven participants received oral coenzyme Q10 (100?mg/day) supplementation, and seven participants received placebo (glucose) for 8 weeks. At the end of the 8 weeks, a second blood sampling was performed. After a 4-week washout period, placebo was given to the participants who used coenzyme Q10 the first time, and vice versa, and blood sampling was repeated. Plasma was stored at ?80°C until the time of analysis for adiponectin, IL-6, and TNF-α. Both CoQ10 and placebo supplementation did not affect plasma adiponectin and TNF-α levels. IL-6 level increased with coenzyme Q10 supplementation, but this increase did not differ from that seen with placebo supplementation. Coenzyme Q10 supplementation did not affect plasma adiponectin, IL-6, and TNF-α levels in sedentary men.
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KEYWORD
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adiponectin, coenzyme Q10, interleukin-6, tumor necrosis factor-α
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