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KMID : 1161420110140030261
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Journal of Medicinal Food
2011 Volume.14 No. 3 p.261 ~ p.267
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Flaxseed but Not Flaxseed Oil Prevented the Rise in Serum Cholesterol Due to Ovariectomy in the Golden Syrian Hamsters
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Lucas Edralin A.
Mahajan Sachin S.
Soung Do Y.
Lightfoot Stanley A.
Smith Brenda J.
Arjmandi Bahram H.
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Abstract
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This study was designed to investigate whether flaxseed oil (FO) exerts hypocholesterolemic effects similar to ground whole flaxseed (WF) and to gain insight into its hypocholesterolemic mechanism. Forty-eight 6-month-old female Golden Syrian hamsters were either sham-operated (Sham) or ovariectomized (Ovx) and randomly assigned to one of four treatment groups (n?=?12/group) for 90 days: Sham, Ovx, Ovx+WF, or Ovx+FO. Hamsters in the Sham and Ovx groups were fed a semipurified diet (control), whereas Ovx+WF and Ovx+FO received the same basic diet supplemented with either WF (15% wt/wt) or FO (amount equivalent to the oil contribution of WF). Ovariectomy significantly (P?
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KEYWORD
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cholesterol, flaxseed, flaxseed oil, hamsters, ovariectomy
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