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KMID : 1161420140170090972
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Journal of Medicinal Food
2014 Volume.17 No. 9 p.972 ~ p.978
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Ameliorative Effects of Monascus pilosus-Fermented Black Soybean (Glycine max L. Merrill) on High-Fat Diet-Induced Obesity
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Oh Hong-Geun
Kang Young-Rye
Lee Hak-Yong
Kim Jung-Hoon
Shin Eun-Hye
Lee Bong-Gun
Park Sang-Hoon
Moon Dae-In
Kim Ok-Jin
Lee In-Ae
Choi Jong-Keun
Lee Ji-Ean
Park Kwang-Hyun
Suh Joo-Won
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Abstract
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The purpose of this study was to examine the antiobesity effects of Monascus pilosus-fermented black soybean (F-BS) in C57BL/6 mice with high-fat diet (HFD)-induced obesity. F-BS (oral, 0.5 and 1.0?g/kg per body weight, twice per day) ameliorated obesity by reducing body and liver weight increases, and regulating blood glucose and cholesterol levels in C57BL/6 mice fed a control or HFD with oral administration of F-BS for 12 weeks. F-BS suppressed the growth of epididymal, retroperitoneal, and perirenal fat pads by preventing increases in the adipocyte size. Moreover, the levels of blood glucose, total cholesterol, and leptin were significantly lowered by F-BS administration in a dose-dependent manner. These results indicated that F-BS is a beneficial food supplement for preventing obesity, controlling blood glucose, and lowering cholesterol. Future research strategies should address the mechanisms that selectively regulate obesity, including hyperglycemia and hypercholesterolemia.
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KEYWORD
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anti-obesity effect, fermented black soybean, high-fat diet-induced obesity, hyperglycemia, Glycine max L. Merrill, Monascus pilosus
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