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KMID : 1161420150180080938
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Journal of Medicinal Food
2015 Volume.18 No. 8 p.938 ~ p.940
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Staghorn Sumac Reduces 5-Fluorouracil-Induced Toxicity in Normal Cells
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Wang Sunan
Zhu Fan
Marcone Massimo F.
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Abstract
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Edible staghorn sumac (Rhus hirta) fruit extract was applied in conjunction with chemotherapeutic drug 5-fluorouracil to promote cytotoxicity of the drugs toward human breast cancer cells MCF-7 while protecting normal cells MCF-10A from drug toxicity. Sumac extract would be a promising chemotherapeutic drug conjugate in cancer chemotherapy.
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KEYWORD
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chemotherapeutic drug, 5-fluorouracil, staghorn sumac, toxicity
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