|
KMID : 1161420170200050448
|
|
Journal of Medicinal Food
2017 Volume.20 No. 5 p.448 ~ p.457
|
|
|
Evaluation of White Sesame Seed Oil on Glucose Control and Biomarkers of Hepatic, Cardiac, and Renal Functions in Male Sprague-Dawley Rats with Chemically Induced Diabetes
|
|
Aslam Farhan
Iqbal Sanaullah
Nasir Muhammad
Anjum Aftab Ahmad
Swan Pamela
Sweazea Karen
|
|
|
Abstract
|
|
|
|
White sesame seed oil (WSSO) has been used in cooking and food preparations for centuries. It has many purported health benefits and may be a promising nutraceutical. The primary purpose of this study was to examine the effects of WSSO on fasting blood glucose (GLU) and insulin (INS) in male Sprague-Dawley rats with chemically induced diabetes. A secondary aim was to explore other hematological biomarkers of hepatic, cardiac, and renal function. Sixty-three male Sprague-Dawley rats were randomized into standard diet groups, normal control (NCON) (n?=?21) and diabetic control (DCON) (n?=?21), and a diabetic sesame oil (DSO) (n?=?21) group, which were fed a diet containing 12% WSSO. Blood samples were analyzed at 0, 30, and 60 days. Differences between groups and across days were assessed with two-way repeated measures analysis of variance. At baseline, GLU and INS were similar in both diabetic groups, mean 248.4?±?2.8?mg/dL and mean 23.4?±?0.4?μU/mL, respectively. At 60 days, GLU was significantly (P?
|
|
|
KEYWORD
|
|
|
diabetes, insulin, sesame oil, Sprague-Dawley rats, streptozotocin
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|