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KMID : 1161420170200070709
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Journal of Medicinal Food
2017 Volume.20 No. 7 p.709 ~ p.719
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Minor Constituents in Rice Bran Oil and Sesame Oil Play a Significant Role in Modulating Lipid Homeostasis and Inflammatory Markers in Rats
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Yalagala Poorna C. R.
Sugasini Dhavamani
Ramaprasad Talahalli Ravichandra
Lokesh Belur Ramaswamy
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Abstract
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The effects of feeding rats with groundnut oil (GNO), rice bran oil (RBO), and sesame oil (SESO) on serum lipids, liver lipids, and inflammatory markers were evaluated in rats. Male Wistar rats were fed with AIN-93 diet supplemented with 10?wt% of GNO, RBO, and SESO in the form of native (N) and minor constituent-removed (MCR) oils. Rats given RBO and SESO showed significant reduction in serum and liver lipids, 8-hydroxy-2-deoxyguanosine, cytokines in liver, and eicosanoids in leukocytes as compared with the rats given GNO and MCR oils. The rats fed with native oils of RBO and SESO showed an upregulation of sterol regulatory element-binding protein (SREBP)-2 and peroxisome proliferator-activated receptor gamma (PPARγ) and downregulation of nuclear factor-kappa B (NF-κB) p65. These effects of native oil were significantly compromised when rats were given MCR oils. In conclusion, the minor constituents significantly support the hypolipidemic and anti-inflammatory properties of RBO and SESO.
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KEYWORD
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hypocholesterolemic effects, inflammatory mediators, minor constituents, oxidative stress markers, rice bran oil, sesame oil
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