|
KMID : 1161420170200070720
|
|
Journal of Medicinal Food
2017 Volume.20 No. 7 p.720 ~ p.723
|
|
|
Blood Pressure-Lowering Effects of Alacalase-Hydrolyzed Camellia Seed Hull In Vitro and in Spontaneous Hypertensive Rats
|
|
Lim Ho-Jeong
Kim Mi-So
Kim Da-Som
Kim Young-Jun
Lee Jin-Hyup
Pan Jeong-Hoon
Shin Eui-Cheol
Kim Jae-Kyeom
|
|
|
Abstract
|
|
|
|
High blood pressure is one of the major risk factors for various diseases and angiotensin-converting enzyme (ACE) plays a critical role in blood pressure regulation. In our study, the responsive surface methodology was adopted to establish optimal Alcalase-hydrolysis conditions of camellia seed hull against ACE activity. The optimum conditions are hydrolysis temperature of 50.98°C, enzyme/substrate ratio of 2.85%, and hydrolysis pH of 7.12. In an animal feeding study, spontaneously hypertensive rats were treated with either a low or high dose of hydrolyzed Camellia japonica seed cake over 5 weeks. Even though systolic blood pressure was not statistically different, the high dose of C. japonica hydrolysate lowered diastolic blood pressure (106?±?4.4?mmHg vs. 145?±?5.9?mmHg) at the 5th week. A similar trend was also observed in serum ACE activity. Considering that this camellia seed hull is a major resource of this plant, our study provides important data to utilize this plant for both academic and industrial applications.
|
|
|
KEYWORD
|
|
|
alcalase, angiotensin-converting enzyme, antihypertensive effect, Camellia japonica, spontaneously hypertensive rat
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|