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KMID : 1161420180210020159
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Journal of Medicinal Food
2018 Volume.21 No. 2 p.159 ~ p.166
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Deer Bone Extract Supplementation for Mild-to-Moderate Knee Osteoarthritis Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial
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Shin Dong-Seok
Kim Eun-Ae
Kim Yoon-Young
Kim Min-Seo
Kim Jong-Hoon
Ahn Chang-Won
Park Soo-Hyun
Lee Ki-Won
Kim Jae-Hwa
Kim Ji-Yeon
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Abstract
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In this randomized, double-blind, placebo-controlled study, we evaluated the efficacy of deer bone extract (DBE) in participants with knee osteoarthritis (OA). We enrolled 50 participants aged 50?70 years, having knee OA with a Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score ≥5.0. The participants were assigned to the placebo or DBE group (550?mg/day) for 12 weeks. The outcome measures were as follows: pain score on the visual analog scale (VAS); WOMAC score; and blood and urine biomarkers. In the DBE group, VAS scores, WOMAC total scores, and WOMAC subscores (for pain, stiffness, and physical function) improved significantly compared with the baseline values. However, there was no significant difference in outcomes between the DBE and placebo groups. The present findings suggest that DBE may mildly reduce joint pain and stiffness and improve joint function in patients with painful knee OA.
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KEYWORD
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deer bone extract, osteoarthritis, VAS pain score, WOMAC score
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