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KMID : 1161420190220010001
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Journal of Medicinal Food
2019 Volume.22 No. 1 p.1 ~ p.13
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Lactobacillus Strains Alleviated Aging Symptoms and Aging-Induced Metabolic Disorders in Aged Rats
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Hor Yan-Yan
Ooi Cheong-Hwa
Khoo Boon-Yin
Choi Sy-Bing
Seeni Azman
Shamsuddin Shaharum
Oon Chern-Ein
Ong Kee-Leong
Jeong Woo-Sik
Liong Min-Tze
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Abstract
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Aging is an inevitable and ubiquitous progress that affects all living organisms. A total of 18 strains of lactic acid bacteria (LAB) were evaluated on the activation of adenosine monophosphate-activated protein kinase (AMPK), an intracellular energy sensor mediating lifespan extension. The cell-free supernatant (CFS) of Lactobacillus fermentum DR9 (LF-DR9), Lactobacillus paracasei OFS 0291 (LP-0291), and Lactobacillus helveticus OFS 1515 (LH-1515) showed the highest activation of AMPK and was further evaluated. The phosphorylation of AMPK by these three LAB strains was more evident in U2OS and C2C12 cells, compared to the other cell lines and control (P?
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KEYWORD
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AMPK, antiaging, bone, LAB, metabolism, muscle, probiotic, telomere
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