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KMID : 1188320120060040493
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Gut and Liver
2012 Volume.6 No. 4 p.493 ~ p.500
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Long-Term Outcome of Cystic Lesions in the Pancreas: A Retrospective Cohort Study
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Ahn Dong-Won
Lee Sang-Hyub
Kim Jai-Hwan
Yoon Won-Jae
Hwang Jin-Hyeok
Jang Jin-Young
Ryu Ji-Kon
Kim Yong-Tae
Kim Sun-Whe
Yoon Yong-Bum
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Abstract
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Background/Aims:The management guidelines for cystic lesions of the pancreas (CLPs) are not yet well established. This study was performed to document the long-term clinical outcome of CLPs and provide guidelines for the management and surveillance of CLPs.
Methods:In this retrospective cohort study, an additional follow-up was performed in 112 patients with CLPs enrolled from 1998 to 2004 during a previous study.
Results:During follow-up for the median period of 72.3 months, the size of the CLPs increased in 18 patients (16.1%). Six of these patients experienced growth of their CLPs after 5 years of follow-up. Twenty-six patients underwent surgery during follow-up, and four malignant cysts were detected. The overall rate of malignant progression during follow-up was 3.6%. The presence of mural nodules or solid components was independently associated with the presence of malignant CLPs. Seven patients underwent surgery after 5 years of follow-up. The pathologic findings revealed malignancies in two patients. There was only one pancreas-related death during follow-up.
Conclusions:The majority of CLPs exhibit indolent behavior and are associated with a favorable prognosis. However, long-term surveillance for more than 5 years should be performed because of the potential for growth and malignant transformation in CLPs.
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KEYWORD
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Pancreatic cyst, Natural history, Prognosis
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