|
KMID : 1188320140080010102
|
|
Gut and Liver
2014 Volume.8 No. 1 p.102 ~ p.108
|
|
|
Is a Preoperative Assessment of the Early Recurrence of Pancreatic Cancer Possible after Complete Surgical Resection?
|
|
Marco La Torre
Giuseppe Nigri
Annalisa lo Conte
Federica Mazzuca
Simone Maria Tierno
Adelona Salaj
Paolo Marchetti
Vincenzo Ziparo
Giovanni Ramacciato
|
|
|
Abstract
|
|
|
Background/Aims:The prognosis of pancreatic adenocarcinoma (PAC) is poor. The serum carbohydrate antigen 19-9 (CA 19-9) level has been identified as a prognostic indicator of recurrence and reduced overall survival. The aim of this study was to identify preoperative prognostic factors and to create a prognostic model able to assess the early recurrence risk for patients with resectable PAC.
Methods:A series of 177 patients with PAC treated surgically at the St. Andrea Hospital of Rome between January 2003 and December 2011 were reviewed retrospectively. Univariate and multivariate analyses were utilized to identify preoperative prognostic indicators.
Results:A preoperative CA 19-9 level >228 U/mL, tumor size >3.1 cm, and the presence of pathological preoperative lymph nodes statistically correlated with early recurrence. Together, these three factors predicted the possibility of an early recurrence with 90.4% accuracy. The combination of these three preoperative conditions was identified as an independent parameter for early recurrence based on multivariate analysis (p=0.0314; hazard ratio, 3.9811; 95% confidence interval, 1.1745 to 15.3245).
Conclusions:PAC patient candidates for surgical resection should undergo an assessment of early recurrence risk to avoid unnecessary and ineffective resection and to identify patients for whom palliative or alternative treatment may be the treatment of choice
|
|
|
KEYWORD
|
|
|
Pancreatic neoplasms, Early recurrence, Preoperative CA 19-9, Prognosis, Pancreatic adenocarcinoma
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|