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KMID : 1188520200160010052
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Korean Journal of Clinical Oncology
2020 Volume.16 No. 1 p.52 ~ p.56
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What predicts better prognosis in elderly breast cancer patients?
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Jung Youn-Joo
Lee Seung-Ju
Kim Hyun-Yul
Paik Hyun-June
Jung Chang-Shin
Kim Jee-Yeon
Jung Hyuk-Jae
Lee Seok-Won
Kim Choong-Rak
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Abstract
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Purpose: As we enter an aging society, the number of elderly patients with breast cancer is increasing. We assessed the prognostic factors for breast cancer recurrence or metastasis in patients over the age of 65 years by analyzing tumor characteristics and long-term clinical outcomes.
Methods: In this retrospective study, the data of 286 breast cancer patients aged 65 years and older, who underwent treatment at the Pusan National University Hospital and Pusan National University Yangsan Hospital from 2008 to 2014, were analyzed. The patients were divided into two groups: those with recurrence or metastasis and those without. Cox-regression model was used to analyze the risk factors for recurrence or metastasis. Kaplan-Meier method was used to analyze survival rates by the log-rank test.
Results: Among the 286 patients with invasive breast cancer, 43 patients (15.0%) had recurrence or distant metastasis during a median follow-up period of 61 months. Advanced stages of breast cancer and patients who are not adapted to endocrine therapy were associated with poor prognosis.
Conclusion: In this study, advanced stages of breast cancer and endocrine therapy were the prognostic factors for breast cancer recurrences or metastases. Early detection of elderly breast cancer generally increases the possibility of diagnosis at an earlier stage, which can lead to a better prognosis. Moreover, endocrine therapy should be administered to elderly patients who manifest favorable intrinsic subtypes of breast cancer.
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KEYWORD
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Breast neoplasms, Elderly, Clinical characteristics, Prognosis
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