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KMID : 1189420020150020118
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2002 Volume.15 No. 2 p.118 ~ p.130
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Experimental Effects of Taklihwangki-Tang on the Anti-Cancer And Immuno-Action
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Jeong Dong-Hwan
Choi Jung-Hwa
Kim Jong-Han
Jeong Hyun-Woo
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Abstract
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Taklihwangki-Tang was a drug that treated carbuncle and cellulitis. So, the purpose of this Study was to investigate effect of Taklihwangki-Tang on the anti-cancer and proliferation of immunocytes, nitric oxide(NO) production of peritoneal macrophages. We used Taklihwangki-Tang extract(THT) with freeze-dried, 8wks-old male mice and cancer cell lines(L1210, S-180) for this Study. The proliferation of cells was tested using a colorimetric tetrazoliun assay(MTT assay). The results of this Study were obtained as follow ; THT was showed cytotoxicity on the L1210 and S-180 cell lines, increased proliferation of thymocytes. And the combined effects of THT and vincristine were became cytotoxicity of cancer cell lines and increased significantly proliferation of thymocytes. THT accelerated proliferation of thymocytes in normal mice, and decreased significantly proliferation of L1210 cells and accelerated significantly NO production of peritoneal macrophages in L1210 cells transplanted mice. This results suggest that THT inhibit proliferation of cancer cells by becoming immunocytes activity(NO production, proliferation of T-cell).
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KEYWORD
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