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KMID : 1189420030160030082
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2003 Volume.16 No. 3 p.82 ~ p.95
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Effect of Youn-Gyo-Pae-Doc-San on the Release of Thymus and Activation-Regulated Chemokine(TARC) in Human Bronchial Epithelial Cell
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Lee Kyung-Yeob
Kim Hee-Taek
Kim E-Hwa
Nam Chang-Gyu
Ryu Ju-Hyun
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Abstract
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Chemokines are important for the recruitment of leukocytes to sites of infection, which is essential in host defense. The thymus and activation-regulated chemokine (TARC) is a CC chemokine which potentially plays a role via a paracrine mechanism in the development of allergic respiratory diseases. Objectives : The objective of this study is to investigate the effect of Youn-Gyo-Pae-Doc-San on the secretion of TARC of human bronchial epithelial cell Methods : Enzyme-linked immunosorbent assay (ELISA) was performed to detect the secretion of TARC. The cytotoxicity was measured by MTT assay. Results : Youn-Gyo-Pae-Doc-San significantly inhibited the secretion of TARC with a dose -dependant manner. The effective dosage did not have the cytotoxicity on human bronchial epithelial cell. Conclusions : Results of our study show that Youn-Gyo-Pae-Doc-San would play an important role in modulation of TARC in human bronchial epithelial cells.
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KEYWORD
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Thymus and activation-regulated chemokine(TARC) , Youn-Gyo-Pae-Doc-San , Human bronchial epithelial cells , A549
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