|
KMID : 1189420090220010120
|
|
Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2009 Volume.22 No. 1 p.120 ~ p.132
|
|
|
The Effects of Yukmijihwang-tang on Atopic Dermatitis of NC/Nga Mouse
|
|
Cho Jae-Hoon
Kim Yoon-Bum
|
|
|
Abstract
|
|
|
Objective : Yukmijihwang-tang is one of the important medicines for blood- deficiency and yin-deficiency. Atopic dermatitis usually shows dampness-heat pattern in its acute stage and blood-deficiency or yin-deficiency pattern in its chronic stage. Therefore, I hypothesized that Yukmijihwang-tang is effective on atopic dermatitis and investigated the effects of Yukmijihwang-tang on NC/Nga mice’s atopic dermatitis induced by DNCB.
Methods : The NC/Nga mice with atopic dermatitis were divided into four groups: three experimental groups and one control group. The experimental groups were respectively put on 2.5g(YM-2.5), 5g(YM-5) and 10g(YM-10) of Yukmijihwang-tang extract per their weight once a day for 10 days while the control group was fed normal saline. After 10 days, I measured TEWL(transepidermal water loss), observed scratching behaviors, conducted a skin biopsy and checked levels of Total IgE, IL-4 and IFN-? on NC/Nga mice.
Results : 1. Yukmijihwang-tang significantly suppressed skin dryness. In particular, YM-5 and YM-10 had better skin hydration than YM-2.5. 2. Yukmijihwang-tang significantly suppressed pruritus while there was no significant difference among the experimental groups. 3. Yukmijihwang-tang retained skin structure(epidermis, dermis and subcutaneous fat). 4. Yukmijihwang-tang reduced Total IgE level while there was no significant difference between the control group and the experimental groups. 5. Yukmijihwang-tang did not reduce IL-4(Th2 cytokine) level. 6. Yukmijihwang-tang significantly reduced IFN-?(Th1 cytokine) level. In particular, YM-2.5 and YM-5 had lower IFN-? level than YM-10.
Conclusion : The results suggest that Yukmijihwang-tang suppresses skin dryness and pruritus, retains skin structure and is effective on chronic atopic dermatitis which is associated with Th1 cytokines in the immune response.
|
|
|
KEYWORD
|
|
|
Yukmijihwang-tang, Chronic, Atopic dermatitis, IFN-?
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|