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KMID : 1195620240170010001
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Clinical and Experimental Otorhinolaryngology
2024 Volume.17 No. 1 p.1 ~ p.14
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Hair Cell Regeneration: From Animals to Humans
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Choi Sung-Won
Julia M. Abitbol
Alan G. Cheng
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Abstract
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Cochlear hair cells convert sound into electrical signals that are relayed via the spiral ganglion neurons to the central audi-tory pathway. Hair cells are vulnerable to damage caused by excessive noise, aging, and ototoxic agents. Non-mammals canregenerate lost hair cells by mitotic regeneration and direct transdifferentiation of surrounding supporting cells. However,in mature mammals, damaged hair cells are not replaced, resulting in permanent hearing loss. Recent studies have uncov-ered mechanisms by which sensory organs in non-mammals and the neonatal mammalian cochlea regenerate hair cells,and outlined possible mechanisms why this ability declines rapidly with age in mammals. Here, we review similarities anddifferences between avian, zebrafish, and mammalian hair cell regeneration. Moreover, we discuss advances and limitationsof hair cell regeneration in the mature cochlea and their potential applications to human hearing loss.
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KEYWORD
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Hearing Loss, Cochlea, Hair Cells, Regeneration
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