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KMID : 1197720110040010041
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대한파킨슨병 및 이상운동질환 학회지
2011 Volume.4 No. 1 p.41 ~ p.45
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Cognitive Impairments in Multiple System Atrophy of the Cerebellar Type
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Hong Hyun J.
Song Sook-Keun
Lee Phil-Hyu
Sohn Young-Ho
Lee Ji-Eun
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Abstract
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Background and Purpose: We investigated the cognitive profiles in a large sample of patients with multiple system atrophy-cerebellar ataxia (MSA-C) and compared directly them in patients with clinical diagnosis of probable MSA-C without dementia and control subjects with intact cognition.
Methods: We prospectively enrolled 26 patients with clinical diagnosis of probable MSA-C. All patients underwent a standardized neuropsychological test of the Seoul Neuropsychological Screening Battery.
Results: The score of Korean version of the Mini- Mental State Examination was significantly lower in patients with MSA-C (27.2 ± 2.5) than in control subjects (28.9 ± 1.0, p = 0.003). Patients with MSA-C showed a significantly worse performance in visuospatial function, 3 words recall, verbal immediate, delayed and recognition memory, visual delayed memory, phonemic and sementic Controlled Oral Word Association Test, and ideomotor praxis (p < 0.05).
Conclusions: Patients with MSA-C show more severe and more widespread cognitive dysfunctions than controls. Our results also indicate that cognitive dysfunction in patients with MCA-C is suggestive of disruption of the cerebellocortical circuits.
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KEYWORD
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Multiple system atrophy
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