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KMID : 1197720160090010014
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대한파킨슨병 및 이상운동질환 학회지
2016 Volume.9 No. 1 p.14 ~ p.19
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Mechanism of Anti-α-Synuclein Immunotherapy
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Lee Jun-Sung
Lee Seung-Jae
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Abstract
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Immunization therapy targeting α-synuclein has emerged as a promising approach for Parkinson’s disease and perhaps for other synucleinopathies. Several antibodies have shown therapeutic effects in mouse models of synucleinopathies and have alleviated the pathological and behavioral phenotypes of these mice. The mechanisms through which the immunization therapy works were initially puzzling, especially given that α-synuclein is a typical cytosolic protein. Recent studies, however, suggested that extracellular α-synuclein is an important pathogenic entity, and hence, a target for immunotherapy. Here, we review the literature describing immunization therapy for synucleinopathies in mouse models and provide current thoughts on the potential mechanisms underlying the therapeutic effects of α-synuclein immunotherapy.
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KEYWORD
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Synucleinopathy, α-synuclein, Aggregate transmission, Microglia activation, Immunotherapy
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