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KMID : 1197720170100010018
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대한파킨슨병 및 이상운동질환 학회지
2017 Volume.10 No. 1 p.18 ~ p.28
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MicroRNA Biomarkers in Neurodegenerative Diseases and Emerging NanoSensors Technology
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Shah Pratik
Cho Seok-Keun
Thulstrup Peter Waaben
Bjerrum Morten Jannik
Lee Phil-Hyu
Kang Ju-Hee
Bhang Yong-Joo
Yang Seong-Wook
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Abstract
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MicroRNAs (miRNAs) are essential small RNA molecules (20?24 nt) that negatively regulate the expression of target genes at the post-transcriptional level. Due to their roles in a variety of biological processes, the aberrant expression profiles of miRNAs have been identified as biomarkers for many diseases, such as cancer, diabetes, cardiovascular disease and neurodegenerative diseases. In order to precisely, rapidly and economically monitor the expression of miRNAs, many cutting-edge nanotechnologies have been developed. One of the nanotechnologies, based on DNA encapsulated silver nanoclusters (DNA/AgNCs), has increasingly been adopted to create nanoscale bio-sensing systems due to its attractive optical properties, such as brightness, tuneable emission wavelengths and photostability. Using the DNA/AgNCs sensor methods, the presence of miRNAs can be detected simply by monitoring the fluorescence alteration of DNA/AgNCs sensors. We introduce these DNA/ AgNCs sensor methods and discuss their possible applications for detecting miRNA biomarkers in neurodegenerative diseases.
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KEYWORD
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miRNAs, neurodegenerative diseases, silver nanoclusters, DNA sensor
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