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KMID : 1200020190430030368
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Diabetes & Metabolism Journal
2019 Volume.43 No. 3 p.368 ~ p.376
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Serum R-Spondin 1 Is a New Surrogate Marker for Obesity and Insulin Resistance
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Kang Yea-Eun
Kim Ji-Min
Yi Hyon-Seung
Joung Kyong-Hye
Lee Ju-Hee
Kim Hyun-Jin
Ku Bon-Jeong
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Abstract
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Background: Recent in vivo studies indicated that R-spondin 1 (RSPO1) regulates food intake and increases insulin secretion, but its role in humans remains unknown. This study investigated the association between serum levels of RSPO1 and diverse metabolic parameters in humans.
Methods: The study population consisted of 43 subjects with newly diagnosed diabetes mellitus, and 79 non-diabetic participants. Serum levels of RSPO1 were measured using the enzyme-linked immunosorbent assay. The relationships between circulating RSPO1 and diverse metabolic parameters were analyzed.
Results: Circulating RSPO1 levels increased to a greater extent in the obese group than in the lean group. Moreover, serum levels of RSPO1 were higher in the insulin-resistant group than in the insulin-sensitive group. Serum levels of RSPO1 were significantly correlated with a range of metabolic parameters including body mass index, fasting C-peptide, homeostasis model assessment of insulin resistance index, and lipid profile. Moreover, levels were significantly associated with insulin resistance and obesity in non-diabetic subjects.
Conclusion: This study demonstrated the association between serum levels of RSPO1 and a range of metabolic parameters in humans. Serum levels of RSPO1 are significantly related to obesity and insulin resistance, although the precise mechanisms remain unknown.
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KEYWORD
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Insulin resistance, Obesity, RSPO1 protein, human
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