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KMID : 1200820190190020145
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Oriental Pharmacy and Experimental Medicine
2019 Volume.19 No. 2 p.145 ~ p.156
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Preliminary phytochemical and biological investigations of ethanolic extract of Grewia hirsute Vahl
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Das Munny
Debnath Dipti
Hoque Md. Amdadul
Rahman Md. Sohanur
Alam Sumaiya
Islam Azharul
Begum Mst. Marium
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Abstract
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The study was designed to determine the analgesic, anti-inflammatory, anti-diarrheal, antimicrobial activities and presence of phytochemical constituents of ethanolic extract of Grewia hirsute (EGH) Vahl. Analgesic property was investigated by acetic acid, hot plate, and formalin induced writhing method, anti-inflammatory activity was assessed by xylin generated ear edema and carrageenan-induced edema in rat paw, anti-diarrheal study was conducted by castor oil and testing of gut motility using barium sulfate (BaSO4) and anti-microbial activity was assessed by disc diffusion method. In hot plate method, 250 mg/kg b.w. disclosed higher percentage latency elongation. In acetic acid-induced analgesia, percentage of writhing inhibition for 250 and 500 mg/kg b.w doses of plant extract and standard drug were 55%, 70% and 84% respectively. At later phase, 250, 500 mg/kg b.w doses of extract and standard drug showed 66.01%, 76.3% and 82.608% writhing inhibition individually in analgesia induced by formalin. In xylin-induced ear edema, 500 mg/kg b.w. dose showed noticeable inhibition (59.79%) than 250 mg/kg b.w. (48.18%). In carrageenan method, EGH demonstrated significant (p?
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KEYWORD
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Grewia hirsute, Anti-inflammatory, Anti-diarrheal, Anti-microbial activities
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