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KMID : 1200820190190020157
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Oriental Pharmacy and Experimental Medicine
2019 Volume.19 No. 2 p.157 ~ p.165
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Evaluation of the serum sex hormones levels and alkaline phosphatase activity in rats’ testis after administering of berberine in experimental varicocele
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Najaran Hamed
Bafrani Hassan Hassani
Rashtbari Hamid
Izadpanah Fatemeh
Rajabi Mohammad Reza
Kashani Hamed Haddad
Mohammadi Abouzar
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Abstract
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Current study was aimed to investigate the protective effect of berberine (BB) on the serum gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), inhibin B (INHB), testosterone (T) and alkaline phosphatase (Alk-p) activity in the testis of experimental varicocele-induced animals. For the current objective, 30 mature-male Wistar rats were randomly divided into control (n?=?6 rats), control-sham (n?=?6 rats) and experimental groups (n?=?18 rats). The animals in the experimental groups were undergone experimental varicocele and simple laparotomy was conducted in control-sham group. 60 days after varicocele (VCL) induction the experimental group subdivided into: non-treated VCL-induced and 50 mg/kg and 100 mg/kg BB-treated groups (intra-peritoneally). Following 60 days, the animals were euthanized and serum levels of testosterone and testicular activity of alkaline phosphatase were measured. Non-treated VCL-induced animals indicated a significant (P?
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KEYWORD
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Varicocele, Berberine, Gonadotropin-releasing hormone, Inhibin B, Testosterone, Alkaline phosphatase
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