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KMID : 1200820190190030235
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Oriental Pharmacy and Experimental Medicine
2019 Volume.19 No. 3 p.235 ~ p.241
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Curcuma zedoaria (christm.) roscoe inhibits proliferation of MDA-MB231 cells via caspase-cascade apoptosis
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Lourembam Romen Meitei
Yadav Amit Singh
Kundu Gopal C.
Mazumder Pranab Behari
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Abstract
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Curcuma zedoaria is a perennial herb that belongs to Zingiberaceae family, found growing lavishly in Manipur; a north eastern part of India. The traditional usages of the plant is not limited to a particular disease but extended over a large number of diseases. Anti-breast cancer activity of ethyl acetate extract of Curcuma zedoaria was conducted on MDA-MB231 breast cancer cell line with the help of MTT assay technique and the mechanistic pathway was established with the help of western blot technique, confocal microscopy, wound healing migration assay and cell cycle analysis. Cell cytotoxicity test of ethyl acetate extracts showed remarkable result on MDA-MB231 in dose dependent manner (p?
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KEYWORD
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Curcuma Zedoaria, MDA-MB231, Cleaved caspase-9, Bcl-2, Cytochrome C, Anti-metastatic, Apoptosis
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