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KMID : 1200820190190040421
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Oriental Pharmacy and Experimental Medicine
2019 Volume.19 No. 4 p.421 ~ p.433
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Extracts from the trunk bark of Distemonanthus benthamianus Baillon. (Caesalpiniaceae) developed antidiarrhoeal activities in rats and mice
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William Yousseu Nana
Gilbert Ateufack
Shah Abdul Jabbar
Marius Mbiantcha
Mireille Tchoumba Tchoumi Liliane
Vanessa Matah Mba Marthe
Flore Adjouzem Carine
Gires Teboukeu Boungo
Ducret Awouafack Maurice
Khan Taous
Albert Kamanyi
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Abstract
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Distemonanthus benthamianus is used in Cameroon to treat diarrhoeal episodes. The study aimed to evaluate its antidiarrhoeal potential in Wistar rats and BALB/c mice. Extracts were preliminary investigated for phytochemical components, total phenols quantification and DPPH scavenging activity. Their effects were also evaluated against castor oil-induced diarrhoea, prostaglandin-E1-induced fluid accumulation, charcoal meal motility test, as well as against magnesium sulphate-induced diarrhoea and electrolytes regulation. The methanolic extract contains alkaloids, flavonoids, polyphenols, saponins, sterols, tannins and triterpenes while aqueous extract was devoid of sterols and triterpenes. Phenolic compounds were more concentrated in methanolic extract, which also developed significant DPPH scavenging effects. In castor oil-induced diarrhoea, significant (p?
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KEYWORD
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Distemonanthus benthamianus, Antidiarrhoeal, Prostaglandin-E1, Motility
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