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KMID : 1200820200200020181
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Oriental Pharmacy and Experimental Medicine
2020 Volume.20 No. 2 p.181 ~ p.187
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In-vitro evaluation of antimicrobial, antioxidant, alpha-amylase inhibition and cytotoxicity properties of Cannabis sativa
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Shah Syed Bilal
Sartaj Lubna
Hussain Shahid
Ullah Nabi
Idrees Muhammad
Shaheen Asma
Javed Muhammad Sufyan
Aslam Muhammad Kashif
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Abstract
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Cannabis sativa (C. sativa) is a widespread medicinal plant used for humans and cattles infectious diseases. The current study is carried out to assess phytochemical, antimicrobial, antioxidant, α-amylase inhibition and cytotoxic activity of the Cannabis sativa plant. An appropriate amount of phytochemicals like tannins, flavonoids, lycopene, and β-carotenes is found in C. sativa plant during the phytochemical screening. Among these phytochemicals of C. sativa plant, tannin shows outstanding activity. The plant extracts are assessed for antimicrobial activity against different seven bacterial strains. Notably, the stem part of C. sativa is found to exhibit higher antimicrobial potential than root and leaf. Among the extracts, the antioxidant assays (evaluated through % inhibition of linoleic acid peroxidation assessment) of n-hexane extract of leaf part was highest (80.70%) compared to the others. The plant also contains a potent α-amylase inhibitory potential, the root extract shows maximum inhibition of α-amylase. The cytotoxic effect [evaluated through hemolytic activity as (%) lysis of RBCs against human erythrocytes] of the plant extracts is found insignificant ranging from 1.97 to 5.88. The plant C. sativa keeps a significant amount of bioactive phenolic combinations accompanied by high antimicrobial and antioxidant activities.
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KEYWORD
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Cannabis sativa, Phytochemicals, α-Amylase, Antioxidant, Antimicrobial, Cytotoxicity
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