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KMID : 1200820200200040529
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Oriental Pharmacy and Experimental Medicine
2020 Volume.20 No. 4 p.529 ~ p.544
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Potential nephroprotective effects of resveratrol in drug induced nephrotoxicity: a narrative review of safety and efficacy data
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Shahbazi Foroud
Farvadi Fakhrossadat
Dashti-Khavidaki Simin
Ataei Sara
Shojaei Lida
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Abstract
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Drug induced nephrotoxicity commonly occurs in hospitalized patients and sometimes may complicate treatment outcome, especially in critically ill patients. No universal prophylactic agent is available yet to protect against drug related nephrotoxicity. Many modalities have been applied with different successes. Polyphenolic compounds such as resveratrol have been used both in-vitro and in vivo to prevent drug induced nephrotoxicity. Resveratrol have several antioxidant, antiplatelet and nitric oxide releasing properties in preclinical studies. In this review, we discuss recent studies that evaluated resveratrol protective effects, the mechanism of action and safety issues on drug induced nephrotoxicity.
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KEYWORD
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Formulation, Medication, Nephrotoxicity, Resveratrol
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