|
KMID : 1200820200200040563
|
|
Oriental Pharmacy and Experimental Medicine
2020 Volume.20 No. 4 p.563 ~ p.570
|
|
|
Baccharis trimera (carqueja) promotes gastroprotection on ethanol-induced acute gastric ulcer
|
|
Rabelo Ana Carolina Silveira
Camini Fernanda Caetano
Bittencourt Melissa Maia
Lacerda Kissyla
de Lima Wanderson Geraldo
Costa Daniela Caldeira
|
|
|
Abstract
|
|
|
|
One of the factors that can promote gastric ulcer is the acute and/or chronic consumption of ethanol. One of the most used therapeutic measures is the use of proton pump inhibitor, like omeprazole. However, these drugs have several side effects, making it necessary to search for new alternatives. To investigate the gastroprotective effect of Baccharis trimera (carqueja) we used an ethanol-induced acute gastric ulcer model. For this, gastric ulcer was induced in rats using absolute ethanol for 2 consecutive days. After analysis of the stomach, an increase in oxidative stress was observed, as well as the reduction of the antioxidant defense. In addition, we observed in histology that there was an increase in inflammatory cells, necrosis, hemorrhage and hyperemia. Treatment with B. trimera was able to decrease oxidative damage as well as improve antioxidant defense. There was also a decrease in inflammation, collagen area and hemorrhage. All the beneficial effects promoted by carqueja were similar to those found by the positive controls used in our study (vitamin C and omeprazole). Analyzing our data, we can conclude that B. trimera presents a gastroprotective effect and should be further studied for its application in gastric ulcer therapy.
|
|
|
KEYWORD
|
|
|
Baccharis trimera, Carqueja, Gastroprotection, Ethanol, Gastric ulcer
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|