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KMID : 1202320110040020121
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Brain & NeuroRehabilitation
2011 Volume.4 No. 2 p.121 ~ p.125
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Effects of Botulinum Toxin A Injection into Salivary Glands of Patients with Brain Lesion Suffering from Posterior Drooling
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Lee Zee-Ihn
Park Dong-Hwi
Jo Dong-Hyun
Choi Won-Duck
Byun Seung-Deuk
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Abstract
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Objective:The aim of the study was to evaluate the effectiveness of ultrasouond-guided salivary gland injection of botulinum toxin A (BTX-A) for posterior drooling.
Method:11 patients with brain lesion (9 cerebral palsy, 1 hypoxic ischemic encephalopathy and 1 mental retardation) with posterior drooling (an initial PDAS score greater than 2) and related pulmonary problems were recruited. Drooling severity was measured at baseline, 4 weeks, 3 months and 6 months after botulinum toxin A injection, by using Teacher Drooling Scale (TDS), Visual Analogue Scales (VAS), Drooling Score System (DSS)-severity, frequency and Posterior Drooling/Aspiration System (PDAS).
Results:The TDS, DSS-severity, DSS-frequency, VAS, PDAS were significantly reduced at 4 weeks and 3 months after BTX-A injection into salivary glands compared to pre-injection (p＜0.05). However, there were no significant changes at 6 months compared to pre-injection level.
Conclusion:BTX-A injection into salivary glands may improve anterior drooling in patients with brain lesions. Furthermore BTX-A injection into salivary glands may also decrease the posterior drooling which might related to respiratory symptoms in aspiration pneumonia.
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KEYWORD
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botulinum toxin type A, drooling, salivary glands
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