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KMID : 1202320140070010001
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Brain & NeuroRehabilitation
2014 Volume.7 No. 1 p.1 ~ p.4
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The Concept of Metaplasticity
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Yoo Woo-Kyoung
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Abstract
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The concept of metaplasticity entails a change in the physiological or biochemical state of synapsesthat alters their ability to generate synaptic plasticity by integrating individual synaptic events. Thecharacteristics of metaplasticity would be the fact that those synaptic changes last in certain periodtime with association of activity in time, homosynaptically or heterosynaptically. Recently introducednon-invasive brain stimulation enables us to observe the metaplastic changes in vivo, which would giveus a insight in developing new effective therapeutic approach based on synaptic plasticity andmetaplasticity.
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KEYWORD
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metaplasticity, neuronal plasticity, transcranial magnetic stimulation
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