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KMID : 1204320200360010026
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Laboratory Animal Research
2020 Volume.36 No. 1 p.26 ~ p.26
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Quisqualis indica extract ameliorates low urinary tract symptoms in testosterone propionate-induced benign prostatic hyperplasia rats
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Kim Dae-Geon
Kwon Hyo-Jeong
Lim Jong-Hwan
Kim Joo-Heon
Lee Kyu-Pil
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Abstract
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Benign prostate hyperplasia (BPH) is a common disease in old-age males, accounting for approximately 77% of morbidity within the age range of 40 to 70?years. It has been shown that morbidity increases with social graying. Quisqualis indica linn (QI) has been used to treat inflammation, stomach pain, and digestion problems. In this study, we evaluated the symptom-regulating effects of QI extract on a testosterone-induced BPH rat model. After inducing BPH in rats using testosterone propionate (TP) injection, we assessed basal intraurethral pressure (IUP) and increments of IUP elicited by electrical field stimulation (5?V, 5, 10, or 20?Hz) or phenylephrine (Phe) (0.01, 0.03, 0.1?mg/kg IV). To induce BPH, 8-week-old rats were subjected to a daily subcutaneous TP (3?mg/kg) injection for 4?weeks. Finasteride (Fina) (10?mg/kg PO) was administered to the rats in the first treatment, while QI (150?mg/kg PO) was administered to those in the second group. Blood pressure was measured together with IUP, after which low urinary tract (LUT), ventral prostate (VP), testicle, and corpus spongiosum were isolated and weighed. Basal IUPs for the Fina- and QI-treated groups were 87.6 and 86.8%, respectively.
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KEYWORD
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Benign prostatic hyperplasia, Quisqualis indica, Intraurethral pressure, Lower urinary tract symptoms
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