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KMID : 1204720090020020102
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International Journal of Stem Cells
2009 Volume.2 No. 2 p.102 ~ p.108
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Stem Cells Transplantation and Huntington’s Disease
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Im Woo-Seok
Lee Soon-Tae
Chu Kon
Kim Man-Ho
Roh Jae-Kyu
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Abstract
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Huntington’s disease (HD) is a progressive and devastating neurodegenerative disorder that results in movement abnormalities, cognitive impairments, dementia, and affective disturbances. As no proven medical therapy for this genetic disease is currently available, symptoms mitigation is the primary treatment for HD. Stem cells can play an important role in cell therapy therapeutic strategies to replace dysfunctional or dying cells in HD. Here, we present a brief overview of the current state of stem cells therapy and of the results obtained in animal models of HD, and discuss neuroprotective approaches that utilize stem cells-derived paracrine factors.
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KEYWORD
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Stem cells, Animal model, Huntington’s disease
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