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KMID : 1204720110040010035
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International Journal of Stem Cells
2011 Volume.4 No. 1 p.35 ~ p.42
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Differentiation into Endoderm Lineage: Pancreatic differentiation from Embryonic Stem Cells
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Lee Dong-Hyeon
Chung Hyung-Min
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Abstract
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The endoderm gives rise to digestive and respiratory tracts, thyroid, liver, and pancreas. Representative disease of endoderm lineages is type 1 diabetes resulting from destruction of the insulin-producing ? cells. Generation of functional ? cells from human embryonic stem (ES) cells in vitro can be practical, renewable cell source for replacement cell therapy for type 1 diabetes. It has been achieved by progressive instructive differentiation through each of the developmental stages. In this article, important studies of differentiation into pancreatic ? cells from ES cells are reviewed through pancreatic developmental stages as definitive endoderm, primitive gut tube/foregut, and pancreatic cells. The investigation of differentiating ES cells from definitive endoderm to pancreas using signaling, arrays, and proteomics is also introduced.
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KEYWORD
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Endoderm, Primitive gut tube, Pancreatic ? cell, Embryonic stem cell
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