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KMID : 1204720150080010054
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International Journal of Stem Cells
2015 Volume.8 No. 1 p.54 ~ p.68
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New Strategies for Overcoming Limitations of Mesenchymal Stem Cell-Based Immune Modulation
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Kim Na-Youn
Cho Seok-Goo
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Abstract
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Mesenchymal stem cells (MSCs) have rapidly been applied in a broad field of immune-mediated disorders since the first successful clinical use of MSCs for treatment of graft-versus-host disease. Despite the lack of supporting data, expectations that MSCs could potentially treat most inflammatory conditions led to rushed application and development of commercialized products. Today, both pre-clinical and clinical studies present mixed results for MSC therapy and the discrepancy between expected and actual efficacy of MSCs in various diseases has evoked a sense of discouragement. Therefore, we believe that MSC therapy may now be at a critical milestone for re-evaluation and re-consideration. In this review, we summarize the current status of MSC-based clinical trials and focus on the discrepancy between expected and actual outcome of MSC therapy from bench to bedside. Importantly, we discuss the underlying limitations of MSCs and suggest a new guideline for MSC therapy in hopes of improving their therapeutic efficacy.
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KEYWORD
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Mesenchymal stem cells, Immune modulation, Clinical trial, Limitation
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