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KMID : 1204720150080020200
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International Journal of Stem Cells
2015 Volume.8 No. 2 p.200 ~ p.208
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Possible Therapeutic Effect of Stem Cell in Atherosclerosis in Albino Rats. A Histological and Immunohistochemical Study
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Abdel-Kawi Samraa H
Hashem Khalid S
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Abstract
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Background: Atherosclerosis is the leading cause of death worldwide. there are no effective approaches to regressing atherosclerosis due to not fully understood mechanisms. Recently, stem cell-based therapies have held promises to various diseases, including vascular diseases.
Aim: The present study aimed at investigating the possible effect of cord blood mesenchymal stem cell (MSC) therapy on atherosclerosis.
Material and Methods: Eighty adult male albino rats were divided into control group (I), atherogenic group (II): subjected to high cholesterol fed diet (200~300 mg/kg body weight) for 12 weeks and 1.8 million units of vitamin D / kg of diet for 6 weeks. Stem cell therapy group (III): injected with stem cells in the tail vein following confirmation of atherosclerosis. Histological, Immunohistochemical and morphometric studies were performed were conducted.
Results: Atherogenic group (II) showed increased aortic thickness, intimal proliferation, smooth muscle proliferation and migration. Increased area % of collagen fibers, iNOS and vimentin immunoreactions were recorded and proved morphometrically. All findings regressed on stem cell therapy.
Conclusion: A definite therapeutic effect of mesenchymal stem cells was found on atherosclerosis.
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KEYWORD
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Mesenchymal stem cells, Atherosclerosis, Cord blood, eNOS, iNOS
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