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KMID : 1204720160090010137
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International Journal of Stem Cells
2016 Volume.9 No. 1 p.137 ~ p.144
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Severe Type 2 Diabetes Induces Reversible Modifications of Endothelial Progenitor Cells Which are Ameliorate by Glycemic Control
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De Pascale Maria Rosaria
Bruzzese Giuseppe
Crimi Ettore
Grimaldi Vincenzo
Liguori Antonio
Brongo Sergio
Barbieri Michelangela
Picascia Antonietta
Schiano Concetta
Sommese Linda
Ferrara Nicola
Paolisso Giuseppe
Napoli Claudio
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Abstract
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Background: Circulating endothelial progenitors cells (EPCs) play a critical role in neovascularization and endothelial repair. There is a growing evidence that hyperglycemia related to Diabetes Mellitus (DM) decreases EPC number and function so promoting vascular complications.
Aim of the Study: This study investigated whether an intensive glycemic control regimen in Type 2 DM can increase the number of EPCs and restores their function.
Methods: Sixty-two patients with Type 2 DM were studied. Patients were tested at baseline and after 3 months of an intensive regimen of glycemic control. The Type 2 DM group was compared to control group of subjects without diabetes. Patients with Type 2 DM (mean age 58.2±5.4 years, 25.6% women, disease duration of 15.4±6.3 years) had a baseline HgA1c of 8.7±0.5% and lower EPC levels (CD34+/KDR+) in comparison to healthy controls (p<0.01).
Results: The intensive glycemic control regimen (HgA1c decreased to 6.2±0.3%) was coupled with a significant increase of EPC levels (mean of 18%, p<0.04 vs. baseline) and number of EPCs CFUs (p<0.05 vs. baseline).
Conclusion: This study confirms that number and bioactivity of EPCs are reduced in patients with Type 2 DM and, most importantly, that the intensive glycemic control in Type 2 DM promotes EPC improvement both in their number and in bioactivity.
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KEYWORD
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Type 2 diabetes, Endothelial progenitor cells, Vascular disease, Regenerative medicine
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