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KMID : 1204720190120010008
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International Journal of Stem Cells
2019 Volume.12 No. 1 p.8 ~ p.20
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Role of HIF1α Regulatory Factors in Stem Cells
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Lee Hyun-Jik
Jung Young-Hyun
Choi Gee-Euhn
Kim Jun-Sung
Chae Chang-Woo
Han Ho-Jae
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Abstract
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Hypoxia-inducible factor 1 (HIF1) is a master transcription factor that induces the transcription of genes involved in the metabolism and behavior of stem cells. HIF1-mediated adaptation to hypoxia is required to maintain the pluripotency and survival of stem cells under hypoxic conditions. HIF1 activity is well known to be tightly controlled by the alpha subunit of HIF1 (HIF1α). Understanding the regulatory mechanisms that control HIF1 activity in stem cells will provide novel insights into stem cell biology under hypoxia. Recent research has unraveled the mechanistic details of HIF1α regulating processes, suggesting new strategies for regulating stem cells. This review summarizes recent experimental studies on the role of several regulatory factors (including calcium, 2-oxoglutarate-dependent dioxygenase, microtubule network, importin, and coactivators) in regulating HIF1α activity in stem cells.
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KEYWORD
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Stem cells, Hypoxia-inducible factor 1 alpha (HIF1α), Calcium, 2-Oxoglutrate-dependent dioxygenase (2OGDD), Microtubule, Importin
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