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KMID : 1225720130050030155
Allergy, Asthma & Immunology Research : AAIR
2013 Volume.5 No. 3 p.155 ~ p.161
Relationships Between Exhaled Nitric Oxide and Atopy Profiles in Children With Asthma
Jang Won-Nyung

Park In-Su
Choi Chang-Hee
Harmin Samuel
Bauer Siegfried
Seo Sung-Chul
Choi Ic-Sun
Choung Ji-Tae
Yoo Young
Abstract
Purpose: We examined whether fractional exhaled nitric oxide (FeNO) levels are associated with atopy profiles in terms of mono-sensitization and poly-sensitization in asthmatic children.

Methods: A total of 119 children underwent an assessment that included FeNO measurements, spirometry, methacholine challenge, and measurement of blood eosinophil count, serum total IgE, and serum eosinophil cationic protein (ECP). We also examined sensitization to five classes of aeroallergens (house dust mites, animal danders, pollens, molds, and cockroach) using skin prick testing. The children were divided into three groups according to their sensitization profiles to these aeroallergens (non-sensitized, mono-sensitized, and poly-sensitized).

Results: The geometric means (range of 1 SD) of FeNO were significantly different between the three groups (non-sensitized, 18.6 ppb [10.0-34.7 ppb]; mono-sensitized, 28.8 ppb [16.6-50.1 ppb]; and poly-sensitized, 44.7 ppb [24.5-81.3 ppb], P=0.001). FeNO levels were correlated with serum total IgE concentrations, peripheral blood eosinophilia, and serum ECP levels to different degrees.

Conclusions: FeNO levels vary according to the profile of atopy, as determined by positive skin prick test results to various classes of aeroallergens. FeNO is also moderately correlated with serum total IgE, blood eosinophilia, and serum ECP. These results suggest that poly-sensitized asthmatic children may have the highest risk of airway inflammation.
KEYWORD
Atopy, asthma, child, fractional exhaled nitric oxide, mono-sensitization, poly-sensitization
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