|
KMID : 1225720160080060522
|
|
Allergy, Asthma & Immunology Research : AAIR
2016 Volume.8 No. 6 p.522 ~ p.526
|
|
|
Plasma Levels of Matrix Metalloproteinase-9 in Children With Chronic Spontaneous Urticaria
|
|
Fatih Dilek
Deniz Ozceker
Zeynep Tamay
Siddika Kesgin
Abdurrahim Kocyigit
Nermin Guler
|
|
|
Abstract
|
|
|
Purpose:Chronic spontaneous urticaria (CSU) is a disease that is primarily seen in adults and is comparatively rare in children. Consequently, only a few studies have focused on the pathogenesis of the disease in children. This study investigated the possible role of metalloproteinase-9 (MMP-9) in the pathogenesis of CSU in children.
Methods:The study group was composed of 54 children with CSU; 34 healthy children comprised the control group. The demographic and clinical features of the study group were extensively evaluated, and laboratory assessments were also performed. An enzyme-linked immunosorbent assay was used to evaluate levels of plasma MMP-9. Disease activity was quantified using the urticaria activity score (UAS).
Results:The median value of plasma MMP-9 was 108.9 ng/mL (interquartile range, 93.3-124.1) in the CSU group and 87.8 ng/mL (69.4-103.0) in the control group. The difference between the 2 groups was statistically significant (P<0.001). Also, MMP-9 levels showed a significant positive correlation with UAS (rho=0.57, P<0.001). Twenty-six percent of patients had positive autologous serum skin test (ASST) results. Neither UAS nor plasma MMP-9 levels were significantly different between ASST-positive and -negative patients (P>0.05).
Conclusions:Plasma MMP-9 levels were elevated in children with CSU and were positively correlated with disease activity. MMP-9 may be both a good biomarker of disease activity and a potential therapeutic target in CSU.
|
|
|
KEYWORD
|
|
|
Chronic spontaneous urticaria, children, disease severity, MMP-9
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|