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KMID : 1237720100430040269
Anatomy & Cell Biology
2010 Volume.43 No. 4 p.269 ~ p.279
Control of neuronal migration through rostral migration stream in mice
Sun Woong

Kim Hyun
Moon Young-Hye
Abstract
During the nervous system development, immature neuroblasts have a strong potential to migrate toward their destination. In the adult brain, new neurons are continuously generated in the neurogenic niche located near the ventricle, and the newly generated cells actively migrate toward their destination, olfactory bulb, via highly specialized migratory route called rostral migratory stream (RMS). Neuroblasts in the RMS form chains by their homophilic interactions, and the neuroblasts in chains continually migrate through the tunnels formed by meshwork of astrocytes, glial tube. This review focuses on the development and structure of RMS and the regulation of neuroblast migration in the RMS. Better understanding of RMS migration may be crucial for improving functional replacement therapy by supplying endogenous neuronal cells to the injury sites more efficiently.
KEYWORD
Neuronal migration, Rostral migratory stream, Neuroblasts, Adult neurogenesis
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