KMID : 1237720100430040332
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Anatomy & Cell Biology 2010 Volume.43 No. 4 p.332 ~ p.339
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Expression of ErbB4 in the apoptotic neurons of Alzheimer¡¯s disease brain
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Woo Ran-Sook
Lee Ji-Hye Yu Ha-Nul Song Dae-Yong Baik Tai-Kyoung
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Abstract
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Neuregulin-1 (NRG1) signaling participates in the synaptic plasticity, maintenance or regulation of adult brain. Although ErbB4, a key NRG1 receptor, is expressed in multiple regions in the adult animal brain, little is known about its localization in Alzheimer¡¯s disease (AD) brains. We previously reported that ErbB4 immunoreactivity showed regional difference in the hippocampus of age-matched control. In the present paper, immunohistochemical characterization of the distribution of ErbB4 receptor in the hippocampus relative to pathology staging were performed in age-matched control (Braak stage 0, n=6) and AD (Braak stage I/V, n=10). Here, we found that ErbB4 immunoreactivity was significantly increased in apoptotic hippocampal pyramidal neurons in the brains of AD patients, compared to those of age-matched control subjects. In AD brains, ErbB4 immunoreactivity was demonstrated to colocalize with the apoptotic signal Bax in apoptotic hippocampal pyramidal neurons. These results suggest that up-regulation of ErbB4 immunoreactivity in apoptotic neuron may involve in the progression of pathology of AD.
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KEYWORD
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Alzheimer¡¯s disease, ErbB4 receptor, Bax, Apoptosis, Neurodegeneration
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