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KMID : 1237720110440010050
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Anatomy & Cell Biology
2011 Volume.44 No. 1 p.50 ~ p.59
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The effects of electrical shock on the expressions of aquaporin subunits in the rat spinal cords
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Yeo Seong-Il
Ryu Hea-Jin
Kim Ji-Eun
Chun Wook
Seo Cheong-Hoon
Lee Boung-Chul
Choi Ihn-Geun
Sheen Seung-Hun
Kang Tae-Cheon
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Abstract
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We analyzed aquaporin (AQP) expression in the rat spinal cord following an electrical shock (ES) to elucidate the roles of AQP in spinal cord injury (SCI) induced by an electrical burn. In control animals, AQP1 immunoreactivity was observed in the small diameter dorsal horn fibers of laminae I and II and in astrocytes and neurons in the spinal cord. Both AQP4 and AQP9 immunoreactivity were detected in astrocytes. One week after the ES, AQP1 immunoreactivity in dorsal horn fibers was downregulated to 83, 61, and 33% of control levels following a 1-, 4-, or 6-second ES, respectively. However, AQP1 immunoreactivity in ventral horn neurons increased to 1.3-, 1.5-, and 2.4-fold of control levels following a 1-, 4-, or 6-second ES, respectively. AQP4 immunoreactivity was upregulated after an ES in laminae I and II astrocytes in a stimulus-intensity independent manner. Unlike AQP1 and AQP4, AQP9 immunoreactivity was unaffected by the ES. These findings indicate that altered AQP immunoreactivity may be involved in SCI following an ES.
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KEYWORD
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Aquaporins, Astrocytes, Neurons, Spinal cord, Electrical shock
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