KMID : 1237720130460040229
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Anatomy & Cell Biology 2013 Volume.46 No. 4 p.229 ~ p.234
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Adiponectin as a new paradigm for approaching Alzheimer¡¯s disease
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Song Ju-Hyun
Lee Jong-Eun
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Abstract
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Adiponectin is an adipocytokine released by the adipose tissue and has multiple roles in the immune system and in the metabolic syndromes such as cardiovascular disease, Type 2 diabetes, obesity and also in the neurodegenerative disorders including Alzheimer¡¯s disease. Adiponectin regulates the sensitivity of insulin, fatty acid catabolism, glucose homeostasis and anti-inflammatory system through various mechanisms. Previous studies demonstrated that adiponectin modulates memory and cognitive impairment and contributes to the deregulated glucose metabolism and mitochondrial dysfunction observed in Alzheimer¡¯s disease. Here, we aim to summarize recent studies that suggest the potential correlation between adiponectin and Alzheimer¡¯s disease.
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KEYWORD
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Adiponectin, Alzheimer¡¯s disease, Brain insulin system, Cognitive impairment
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