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KMID : 1237720170500020077
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Anatomy & Cell Biology
2017 Volume.50 No. 2 p.77 ~ p.85
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The molecular mechanism for nuclear transport and its application
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Kim Yun-Hak
Han Myoung-Eun
Oh Sae-Ock
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Abstract
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Transportation between the cytoplasm and the nucleoplasm is critical for many physiological and pathophysiological processes including gene expression, signal transduction, and oncogenesis. So, the molecular mechanism for the transportation needs to be studied not only to understand cell physiological processes but also to develop new diagnostic and therapeutic targets. Recent progress in the research of the nuclear transportation (import and export) via nuclear pore complex and four important factors affecting nuclear transport (nucleoporins, Ran, karyopherins, and nuclear localization signals/nuclear export signals) will be discussed. Moreover, the clinical significance of nuclear transport and its application will be reviewed. This review will provide some critical insight for the molecular design of therapeutics which need to be targeted inside the nucleus.
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KEYWORD
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Nuclear transport, Nucleoporins, Ran, Karyopherins, Nuclear localization signal
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