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KMID : 1239920200140060553
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Nutrition Research and Practice
2020 Volume.14 No. 6 p.553 ~ p.567
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Vitamin D regulation of adipogenesis and adipose tissue functions
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Nimitphong Hataikarn
Park Eun-mi
Lee Mi-Jeong
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Abstract
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Vitamin D insufficiency is associated with obesity and its related metabolic diseases. Adipose tissues store and metabolize vitamin D and expression levels of vitamin D metabolizing enzymes are known to be altered in obesity. Sequestration of vitamin D in large amount of adipose tissues and low vitamin D metabolism may contribute to the vitamin D inadequacy in obesity. Vitamin D receptor is expressed in adipose tissues and vitamin D regulates multiple aspects of adipose biology including adipogenesis as well as metabolic and endocrine function of adipose tissues that can contribute to the high risk of metabolic diseases in vitamin D insufficiency. We will review current understanding of vitamin D regulation of adipose biology focusing on vitamin D modulation of adiposity and adipose tissue functions as well as the molecular mechanisms through which vitamin D regulates adipose biology. The effects of supplementation or maintenance of vitamin D on obesity and metabolic diseases are also discussed.
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KEYWORD
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Cholecalciferol, adipogenesis, adipose function, obesity, metabolic diseases
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